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Image Search Results
Journal: Journal of Translational Medicine
Article Title: Limonin attenuates hyperlipidemia by regulating the gut microbiota-bile acid-farnesoid X receptor axis
doi: 10.1186/s12967-026-07826-7
Figure Lengend Snippet: Impacts of Limonin upon FXR/FGF15 signaling pathway in intestinal of hyperlipidemia mice. ( A ) Representative picture of immunofluorescence expression in mice intestine. ( B ) The immunofluorescence protein expression of FGF15 in the ileum. ( C ) The immunofluorescence protein expression of FXR in the ileum. ( D ) Ileum mRNA expression levels of Fgf15 . ( E ) Ileum mRNA expression levels of Fxr . ( F ) Ileum mRNA expression levels of Asbt . ( G ) Representative protein bands detected by WB. ( H ) Ileum protein expression levels of FGF15. ( I ) Ileum protein expression levels of FXR. ( J ) Ileum protein expression levels of ASBT. Values are shown as mean ± SD ( n = 3). # P < 0.05, ## P < 0.01 vs. MG and * P < 0.05, ** P < 0.01 vs. NG
Article Snippet: The protein expression of
Techniques: Immunofluorescence, Expressing
Journal: Journal of Translational Medicine
Article Title: Limonin attenuates hyperlipidemia by regulating the gut microbiota-bile acid-farnesoid X receptor axis
doi: 10.1186/s12967-026-07826-7
Figure Lengend Snippet: Impacts of Limonin upon FXR/FGF15 signaling pathway in hyperlipidemia mice liver. ( A ) mRNA expression levels of fgf15 in liver. ( B ) mRNA expression levels of Fgfr4 in liver. ( C ) mRNA expression levels of Cyp7a1 in liver. ( D ) Representative picture of immunofluorescence expression in mice liver. ( E ) F Immunofluorescence expression of CYP7A1 in liver. ( F ) Immunofluorescence expression of CYP7A1 in liver. ( G ) Immunofluorescence expression of CYP7A1 in liver. ( H ) FGF15 protein expression levels. ( I ) FGFR4 protein expression levels. ( J ) CYP7A1 protein expression levels. ( K ) Representative protein bands detected by WB. Values are denoted by mean ± SD ( n = 3). # P < 0.05, ## P < 0.01 vs. MG and * P < 0.05, ** P < 0.01 vs. NG
Article Snippet: The protein expression of
Techniques: Expressing, Immunofluorescence
Journal: Journal of Translational Medicine
Article Title: Limonin attenuates hyperlipidemia by regulating the gut microbiota-bile acid-farnesoid X receptor axis
doi: 10.1186/s12967-026-07826-7
Figure Lengend Snippet: Graphical illustration of mechanism mediating anti-hyperlipidemia effects of Limonin. The possible mechanisms by which limonin alleviates dyslipidemia are as follows: (1) Reduced relative abundance of BSH-producing microbes induced by Limonin. (2) Boosted conjugated BAs, particularly TCA, T-αMCA, and T-βMCA acting in antagonistic manner on intestinal FXR, (3) The increased conjugated BAs boosted elimination of BAs via feces, and also as endogenous signaling molecules that inhibited activation of intestinal FXR causing FGF15’s reduced production in the distal ileum. (4) The FGF15 through the enterohepatic circulation to enter mice liver, and regulates liver CYP7A1 expression via negative feedback of FGF15-FGFR4 pathway to promoting the synthesis of TC to BA, thereby reducing TC
Article Snippet: The protein expression of
Techniques: Activation Assay, Expressing